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һ??ECIK???Ƽ???

  ϸ???????յ???ɱ??ϸ????Cytokine-induced killer cell,CIK????һȺ??ֳ????ǿ??ɱ?????Ըߵ?????ЧӦϸ????CIK????ɱ?????õ???ҪЧӦϸ???DZ???CD3+CD8+??CD3+CD56+?????? Ⱥ???????Tϸ?????????Ժ?NKϸ???ķ?MHC??????ɱ???ŵ㣬??ΪNK????Tϸ????

  ????????????Ѫ??Դ??CIK????ϸ???????????ѹ㷺Ӧ?????ٴ????????????ŵ㣺??1??CIKϸ???ǻ??????ϸ????Ӧ???????dz???ȫ????2????Ѫ???٣???? ??Ѫ50ml????3??CIKϸ????ֳ?ٶȿ죬?????ڶ????ڴ??????????????ٴ????Ƶ???Ҫ????4??CIKϸ??ɱ?????Ըߣ?ɱ???׹㣬?Զ?????ҩ????ϸ??ͬ?? ???С???5??CIKϸ???ǵ??͵ĸ??廯????????ģʽ??????Դ?????? T ?ܰ?ϸ??????????ϸ??????󣬿???߶?????ϸ????ɱ?˻??ԣ???????߻???????????????Ӷ???????????ʩ??˫?????á?

  ???ѪCIK?????????ŵ㣺??1????Դ?㷺??ǰ??ϸ???????ߣ???????????????CIK????2???ܰ?ϸ???????࣬???н?ǿ????ֳDZ??????3??????ԭ?Եͣ???ֲ?? ??ֲ?????????Graft-versus-host disease,GVHD)?????ʵ͡???Ѫ??ԴCIKΪ?????????µ????????????ߵ??????????ṩ?˸??ŵ?ѡ?񣬺ܶ໼???ڽ?????ѪCIK???ƺ󣬻??????? ???͹??ܵõ??????ָ???Ϊ???н?һ???????ƺͿ????춨?˻??????????˻??ߵ??ٴ??????ʺ??????????ڡ?


????NK???Ƽ???

  ??Ȼɱ??ϸ??(natural killer cells??NK)????T??Bϸ?????еĵ?????Ⱥ?ܰ?ϸ?????ɷ???????ֱ??ɱ?˰?ϸ??????????Ȼɱ?˻??ԼȲ???ҪԤ???ɿ?ԭ??????Ҳ????Ҫ??????룬???? MHC???ơ?NKϸ????????ֿ???ϸ???Ͳ?????Ⱦϸ???ĵ?һ?????ߣ????˾???ǿ???ɱ?˹????⣬?????к?ǿ?????ߵ??ڹ??ܣ??????????????????ϸ???໥?? ?ã????ڻ????????״̬?????߹??ܡ?

NK ϸ???ڿ????????ƹ????е??ص㣺??1??NKϸ????ֳ?ٶȿ죬?????ڶ????ڴ??????????????ٴ????Ƶ???Ҫ????2??NKϸ??????ʶ???????Ļ??ƣ???????ϸ???? ???????á???3??NKϸ??ɱ?????Ըߣ?ɱ???׹㣬?Զ?????ҩ????ϸ??ͬ?????С???4??????????????Ѫǰ??ϸ?????Ժ?С????5???ֿܵ?????ϸ????????ЧӦϸ ??Fas-FasL????????6??????NKϸ???ǻ??????ϸ????Ӧ???????dz???ȫ??


????TIL???Ƽ???

  ??????????ظ?ˮ????Ϊ??????????ת??????????????ز???֢??Ҳ?ư????ظ?ˮ???ó?????ֶ?????Ч?????ѣ???????Ӧ?????׷??????????ظ?ˮ?е??ܰ?ϸ????һ????????ʽ???????????ܰ?ϸ????TILϸ????????ҪԴ??T?ܰ?ϸ????????????ϸ??????һ????ʶ????????ɱ?˻??Ըߡ?

?? ?????ظ?ˮ?з??벢??ȡTILϸ??????һϵ??ϸ???????????յ?????????????䵽???ߵ??ظ?ǻ?У???ͨ?????¼???;?????????????ã???1??TILϸ?????? ????ʶ??ɱ??????????ϸ??????????????ѪѪ?ܵ????ˣ?ʹ????????????????????ӿ????????ã???Ч????????ϸ????????????????2??TILϸ????????????ϸ ???????????˸?Ĥ????ĵ??????ӣ?????ϸ??????֯???ɷֵ??ͷţ??Լ??ḹĤ??????????????ٽ????˵ĸ?Ĥ??????޸???ʹ????Һ???????գ??Ӷ??ﵽ?????? ?ã???3????߻??????߹??ܡ?


?ġ?DC-CIK???Ƽ???

  DC- CIK????ϸ?????ƣ????????????????????Ѫϸ?????յ???ֻ?Ϊ??ͻ״ϸ????DC???????þ???ԭ?̼?????ͻ״ϸ???յ?CIKϸ????????????????ɱ?????õ? ???Ƽ???????CIK??DCϸ?????й?ͬ???????ɵ?ɱ????ϸ??Ⱥ?壨DC-CIK??????ɱ?˻??Ʊ???Ϊֱ??ɱ?????ú?????ЧӦϸ??????ļ??ɱ?????? ???????ϸ?????߹??ܵ??µĻ??ߣ??????ǰ?Ѫ?????߸?Ϊ?ʺϣ????????????????????΢С????????????á?

  ????ϸ?????????????ٴ??·?չ??DC+CIKϸ??????Ӧ?ã???????Ч??һ????ߣ???????ϸ?????Ƶ??????Ϸ????????????Ʒ?ʽ?????????ص㣺??1?????? ?ԣ?DCϸ??ʶ??ֱ??????????ϸ????CIKϸ??????????ɱ??????ϸ????ֻ??????ϸ????????Ч?????????˺???????֯ϸ??????2????ȫ?ԣ?????????????ϸ?? ɱ??????ϸ?????޶??????á???3???־??ԣ???ǿ????????ϵͳ???ָ????????߹??ܣ??־?ɱ??????ϸ??????4???????ԣ???߻???????????????Ч???ƴ????ʵ?? ??????????????Էš????Ʋ????м?ת?Ƶ?????ϸ??????????????ڲ???????ϸ????΢Сת?Ʋ????5???㷺?ԣ??ؽ?????߻???ȫ???Ļ??????߹??ܣ?ȫ??ʶ ????????ɱ??????ϸ??????Ч??ֹ?????ĸ?????ת?ƣ??????ڸ???????ϸ????????Ч???ơ?


?塢??ԭ??????DCϸ????APDC?????Ƽ???

  ??ԭ??????????ͻ״ϸ????APDC????һ????Զ??????????????????Ե??????????硣????ԭ???Ǵӻ???????????Ѫ?з???ĵ???ϸ???????????ض????????յ???Ϊ ????ǿ??ԭ??ʹ??ܵ?DC???????⾭??????ԭ???????ٽ??????? DC ?????????????ڣ?Я????????ԭ?? DC ?Ὣ??ԭ??Ϣ??ʸ???????Tϸ????ʹ֮????Ӷ??յ??????????????????????ϸ?????Թ??ܵ? T ?ܰ?ϸ????CTL??????????ϸ????????????ɱ?????á?


??????????????DC-CIK????

  ????????????ϸ??????Ϊ????????DCϸ????ʹDCϸ?????????????????ԵĿ?ԭ???ٽ???DCϸ????CIKϸ?????????ﵽһ??ϸ?????????????ߡ???????????ԭ ??DC?????ܳʵݸ?ȫ??Ŀ?ԭ??Ϣ??CIKϸ??????ǿ????????ɱ?????ã??????????????????ݣ??Ҹ??ؿ?ԭ??DC???׷ֻ????죬?Ӷ????ڸ???ٽ?CIKϸ?? ??????ϸ?????ӣ????CIKϸ?????????Կ????????ԡ?


?ߡ? ATTTM???????????????Ƽ???

  ATTTM ???????????????Ƽ??????????¿?????ͨ??˫?????Կ??壨Bispecific Antibodies??BsAb???鵼??Tϸ???????????????????¼???֮һ????ԭ???ǣ????ֱ??ܹ?ʶ??Tϸ????ԭ????????ԭ?????ֿ???ͨ????ѧ????????? ?????ֶ??γɵ?һ??˫?????Կ??????(BsAb???????ֿ?????Ӿ???ͬʱ???Tϸ???ͱ???????????????ԭ??????ϸ????????????˴ӻ??߷??뵥??ϸ???????? ??ϸ???????յ????????????ʱ??˫?????Կ??????????????????Tϸ????ϣ?ͨ??˫?????Կ?????仼?????ڵ?Tϸ???ܹ??????ǿʶ???????????????Ӷ???? ɱ??ЧӦ????Ч?????????


?ˡ?Ƕ?Ͽ?ԭ??????????ε?Tϸ?????????????Ƽ???

  ??????????????????Ժ󣬿?ԭ??????Tϸ???ܹ?ʶ??ɱ??????????ʱ??õ?Ӧ??Ч??Զ???ڱ?׼???ơ?Ƕ?Ͽ?ԭ??????Ϊһ???ܹ????¶???T?ܰ?ϸ????????ϸ???ĵķ??ӣ?Ŀǰ?????ڰ?֢????????????

  Ƕ?Ͽ?ԭ???壨Chimeric Antigen Receptors??CARs???ļ??????ԭ???ǣ???ʶ????????ؿ?ԭ(TAA) ?ĵ???????(scFv)????Ĥ?Ĺ??̼??ṹ????CD28??CD4-1BB????Tϸ???Ļ??????CD3??????????????ڽṹ?򣩽??Ϊһ?壬ͨ???? ??ת??????תȾT?ܰ?ϸ?????????????ε?Tϸ??ͨ?????ﵥ????????ǿ???????ϸ??????????ͬʱͨ?????̼??źźͻ????ı??D??Tϸ??????ֳ??ϸ?????? ?ԣ????????????????ԭ?ĸ??׺??Ժ?T?ܰ?ϸ????ɱ?˻????л???ϣ?ʹ?????????Ե?ʶ???ɱ??????ϸ?????Կ???ȷ?????ض???????ԭ?Ļ??ߵ??ٴ???Ч??߷? ?????ԡ?

  ???????ϣ?????Ƕ?Ͽ?ԭ?????Tϸ????????????Tϸ?????Ʒ?ʽ???????????ƣ??? ʹ?û???????ϸ???????????췴Ӧ???գ??? CAR Tϸ???????Ʊ???ͬһǶ?Ͽ?ԭ????ṹ?????ڶ??????????ƣ??? ????ϸ????????Ӿ??ɳ?ΪǶ?Ͽ?ԭ????DZ?ڰе㣻?? CAR Tϸ?????ù??̲???Ҫ??Ҫ??֯?????Ը????MHC???鵼????MHC??ʧ??ԭ?ʵݸı??????ϸ??ͬ????Ч??


????????QQ?ռ?????΢????Ѷ΢????????΢??

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